期刊
SCIENCE
卷 364, 期 6436, 页码 144-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aau8650
关键词
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资金
- NASA [NNX14AH51G, NNX14AB02G, NNX14AH27G/NCC 9-58, NN13AJ12G, NNX14AN75G, NNX17AB26G, TRISH: NNX16AO69A: 0107, NNX16AO69A: 0061, NNX14AH52G, NNX14AH26G]
- NIH [AG035031]
- NIH/NIDDK [P30 DK017047, P30 DK035816]
- NSF [CCF-1656201]
- DLR space program grant [50WB1535]
- Bert L. and N. Kuggie Vallee Foundation
- WorldQuant Foundation
- Pershing Square Sohn Cancer Research Alliance
- Bill and Melinda Gates Foundation [OPP1151054]
- NASA [NNX14AN75G, 675171, NNX14AH26G, 681222, NNX14AH51G, 683145, NNX14AH52G, 682118, 686935, NNX14AB02G] Funding Source: Federal RePORTER
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.
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