期刊
KOREAN JOURNAL OF PAIN
卷 32, 期 2, 页码 79-86出版社
KOREAN PAIN SOC
DOI: 10.3344/kjp.2019.32.2.79
关键词
Acetic acid; Analgesics; Aromatherapy; Eucalyptus; Formaldehyde; Glyburide; Intraperitoneal injections; Mice; Naloxone; Naltrindole; Rotarod performance test; Opioid antagonists
资金
- Bio & Medical Technology Development Program of the National Research Foundtion (NRF) - Korean government (MSIP MOHW) [2016M3A9B6904244]
- NRF [2015R1D1A1 A01061326]
- National Research Foundation of Korea [2016M3A9B6904244] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Background: The use of aroma oils dates back to at least 3000 B.C., where it was applied to mummify corpses and treat the wounds of soldiers. Since the 1920s, the term aromatherapy has been used for fragrance therapy with essential oils. The purpose of this study was to determine whether the essential oil of Eucalyptus EOE) affects pain pathways in various pain conditions and motor coordination. Methods: Mice were subjected to inhalation or intraperitoneal injection of EOE, and its analgesic effects were assessed by conducting formalin, thermal plantar, and acetic acid tests; the effects of EOE on motor coordination were evaluated using a rotarod test. To determine the analgesic mechanism, 5'-guanidinonaltrindole (kappa-opioid antagonist, 0.3 mg/kg), naltrindole (delta-opioid antagonist, 5 mg/kg), glibenclamide (delta-opioid antagonist, 2 mg/kg), and naloxone (mu-opioid antagonist, 4, 8, 12 mg/kg) were injected intraperitoneally. Results: EOE showed an analgesic effect against visceral pain caused by acetic acid EOE, 45 mg/kg); however, no analgesic effect was observed against thermal nociceptive pain. Moreover, it was demonstrated that EOE did not have an effect on motor coordination. In addition, an anti-inflammatory effect was observed during the formalin test. Conclusions: EOE, which is associated with the mu-opioid pain pathway, showed potential effects against somatic, inflammatory, and visceral pain and could be a potential therapeutic agent for pain.
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