期刊
KIDNEY INTERNATIONAL REPORTS
卷 4, 期 4, 页码 541-550出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ekir.2018.12.011
关键词
angiotensin II type 1 receptor antibody; cytokine; human leukocyte antigen donor-specific antibody; pediatric nephrology; transplantation
资金
- Ruth L. Kirschstein National Research Service Award UCLA Translational Research Grant in Pediatric Nephrology Program [T32 DK104687]
- National Kidney Foundation
- American Society of Nephrology
- Casey Lee Ball Foundation
- Today's and Tomorrow's Children Fund
- Duke Health Scholars Award
- National Institute of Allergy and Infectious Diseases [R01AI13520]
- National Institutes of Health [PO1 AI120944, 5U19AI128913, 1U01AI124319]
- National Center for Advancing Translational Sciences [UL1 TR000124]
Introduction: Angiotensin II type 1 receptor antibody (AT1R-Ab), is a non-human leukocyte antigen (HLA) antibody implicated in poor renal allograft outcomes, although its actions may be mediated through a different pathway than HLA donor-specific antibodies (DSAs). Our aim was to examine serum cytokine profiles associated with AT1R-Ab and distinguish them from those associated with HLA DSA in serially collected blood samples from a cohort of pediatric renal transplant recipients. Methods: Blood samples from 65 pediatric renal transplant recipients drawn during the first 3 months post-transplant, at 6, 12, and 24 months posttransplant, and during suspected episodes of kidney transplant rejection were tested for AT1R-Ab, HLA DSA, and a panel of 6 cytokines (tumor necrosis factor [TNF]-alpha, interferon [IFN]-gamma, interleukin [IL]-8, IL-1 beta, IL-6, and IL-17). Associations between antibodies and cytokines were evaluated. Results: AT1R-Ab, but not HLA DSA, was associated with elevations in TNF-alpha, IFN-gamma, IL-8, IL-1 beta, IL-6, and IL-17. This relationship remained significant even after controlling for relevant clinical factors and was consistent across all time points. In contrast to HLA DSA, AT1R-Ab was associated with elevations in vascular inflammatory cytokines in the first 2 years posttransplant. Conclusions: This profile of vascular cytokines may be informative for clinical monitoring and designing future studies to delineate the distinct pathophysiology of AT1R-Ab-mediated allograft injury in kidney transplantation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据