期刊
MATERIALS LETTERS
卷 209, 期 -, 页码 492-496出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2017.08.093
关键词
Alginate hydrogel; Layer-by-layer assembly; Polymeric composites; Biomaterials; Tissue engineering scaffold
资金
- Natural Science Foundation of China [21366010, 21566009]
Alginate hydrogel undergoes the poor and unstable mechanical strength, and the lack of cell recognition sites for bone tissue engineering. For this reason, we attempted to fabricate alginate/bacterial cellulose nanocrystals-chitosan-gelatin (Alg/BCNs-CS-GT) composite scaffold by the combined method involving the incorporation of bacterial cellulose nanocrystals (BCNs) in alginate matrix, internal gelation by hydroxyapatite-D-glucono-delta-lactone (HAP-GDL) complex and layer-by-layer (LBL) electrostatic assembly of positively charged chitosan (CS) and negatively charged gelatin (GT). The characterization results revealed that Alg/BCNs-CS-GT composite scaffold exhibited good 3D architecture with well-defined porous structure, improved compressive strength and regulated biodegradation. In particular, the excellent bio-compatibility and the reinforcing effect of BCNs, and the outer GT chains containing repetitive motifs of arginine-glycine-aspartic (RGD) sequences favored the attachment, proliferation and differentiation of osteoblastic MC3T3-E1 cells. (C) 2017 Elsevier B.V. All rights reserved.
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