期刊
MATERIALS LETTERS
卷 205, 期 -, 页码 15-19出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2017.06.050
关键词
Biomaterials; Surface; Coaxial electrospray; Heparin microsphere; Sustained release
资金
- 111 Project [B07024]
- Fundamental Research Funds for the Central Universities [2232015A3-02]
- Science and Technology Support Program of Shanghai [16441903803]
- Chinese Postdoctoral Science Foundation [2016M590299]
Improvement of thrombo-resistant properties is vital for vascular substitutes. Heparin, an effective natural anticoagulant, attracted concerns about its incorporate way, releasing profile, and the biological function when applied onto vascular substitutes. Coaxial electrospraying technology was used to develop and form PCL-PEG encapsulated heparin microspheres in this study. Heparin can maintain its activity and sustained release in 15 days with the package and protection of shell layer. When the microspheres were sprayed onto the PCL porous membrane, the materials showed sufficient property in avoiding the platelet adhesion and blood coagulation. (C) 2017 Elsevier B.V. All rights reserved.
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