期刊
ACS APPLIED BIO MATERIALS
卷 2, 期 4, 页码 1751-1761出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b00157
关键词
PLL-g-HPA hydrogels; enzyme-catalyzed reaction; in situ gelation; biocompatibility; degradation property
资金
- National Natural Science Foundation of China [21274085]
- Shanghai Leading Academic Discipline Project [B202]
A hydrogel is required to have a good biocompatibility, permeability for nutrients, and an easy construction procedure for biomedical applications. In particular, in situ forming hydrogels (ISFHs) have triggered considerable interest in their facile preparation methods. Here, an enzyme-prompted ISF, biodegradable poly(L-lysine)graft-4-hydroxyphenylacetic acid (PLL-g-HPA) hydrogel in the conditions of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2) and with a good biocompatibility was developed. The gelling time varied from a couple of seconds to several minutes depending on the amounts of catalyst, H2O2, and polymer. Due to the conveniently ISF means, the fabricated hydrogel could be applied in any form according to the need. The hydrogels display a good biological compatibility, as demonstrated in vitro cell culture and attachment experiments. Besides, the remaining NH2 groups in the hydrogel could be further functionalized for various cell research and bioapplications.
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