期刊
MATERIALS LETTERS
卷 193, 期 -, 页码 1-4出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2017.01.058
关键词
Biomaterials; Polymers; Emulsion electrospinning; Negative voltage; Vascular endothelial growth factor; Controlled release
资金
- Hong Kong RGC [HKU7181/09E, HKU7177/13E]
Electrospun nanofibrous scaffolds providing local delivery of vascular endothelial growth factor (VEGF) have distinctive advantages for vascular tissue engineering. However, more than 90% of VEGF were normally released from scaffolds formed by conventional positive-voltage emulsion electrospinning (PVEES) within the initial 3 days. VEGF molecules bear positive charge. In this investigation, emulsion electrospinning using power supplies of different polarities was studied for producing scaffolds bearing specific electric charge. VEGF-containing poly(lactic-co-glycolic acid) scaffolds with initial potential of -87 and -202 V were formed by negative-voltage emulsion electrospinning (NVEES) at -10 and -20 kV, respectively, which enabled steady and sustained release up to 18 days, exhibiting effective modulation for VEGF release. Compared to VEGF-containing scaffolds formed by PVEES, NVEES-formed scaffolds showed superior performance in promoting endothelial cell functions. (C) 2017 Elsevier B.V. All rights reserved.
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