期刊
MARINE POLLUTION BULLETIN
卷 119, 期 1, 页码 325-331出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.marpolbul.2017.04.033
关键词
Flatfish metamorphosis; Morphological abnormalities; Delayed effects; Thyroid hormones; Polychlorinated biphenyls
资金
- National Natural Science Foundation of China [31202001]
- Natural Science Foundation of Shandong Province [ZR2012CQ010]
- Marine Public Scientific Research Funding Project [2012418012]
This study examined the influence of environmental concentrations of Aroclor 1254 (10, 100, and 1000 ng/L) on metamorphosis of Paralichthys olivaceus, and analyzed the mechanisms in relation to thyroid disruption. Results showed that 100 and 1000 ng/L Aroclor 1254 delayed metamorphosis and that 1000 ng/L Aroclor 1254 caused abnormal morphology. Thyroxine and triiodothyronine levels in the control group were significantly elevated at metamorphic climax, but treatment with 100 and 1000 ng/L delayed the increase in thyroid hormones (THs) and retarded metamorphic processes. In larvae exposed to 1000 ng/L Aroclor 1254, TH levels at metamorphic climax were significantly lower than those of the control group at the same metamorphic stage. We suggest that the effects of Aroclor 1254 on larval metamorphosis can be explained by disruption of thyroid homeostasis. These findings provide a new perspective and biological model for thyroid-disrupting chemicals (TDCs) screening and investigating interference of thyroid function by TDCs.
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