期刊
MEDCHEMCOMM
卷 10, 期 3, 页码 484-487出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9md00031c
关键词
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资金
- Wellcome Trust [110270/A/15/Z]
- Royal Society [RSG\R1\180063]
- Queen's University Belfast
Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as d/l diaminobutyric acid and d-allo-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria.
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