期刊
LIFE-BASEL
卷 9, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/life9010026
关键词
phosphoryl transfer; metabolism; energy currency; mixed anhydride
资金
- Agence Nationale de la Recherche (PeptiSystems project) [ANR-14-CE33-0020]
- Simons Foundation [293,065]
- MRC [MC_UP_A024_1009] Funding Source: UKRI
The very specific thermodynamic instability and kinetic stability of phosphate esters and anhydrides impart them invaluable properties in living organisms in which highly efficient enzyme catalysts compensate for their low intrinsic reactivity. Considering their role in protein biosynthesis, these properties raise a paradox about early stages: How could these species be selected in the absence of enzymes? This review is aimed at demonstrating that considering mixed anhydrides or other species more reactive than esters and anhydrides can help in solving the paradox. The consequences of this approach for chemical evolution and early stages of life are analysed.
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