期刊
CHEMICAL SCIENCE
卷 10, 期 12, 页码 3481-3485出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8sc05618h
关键词
-
资金
- NSF [GOALI SusChEM 1566212]
- Novartis
A new catalyst that derives from commercially available precursors for copper-free, Pd-catalyzed Sonogashira reactions at the sustainable ppm level of precious metal palladium under mild aqueous micellar conditions has been developed. Both the palladium pre-catalyst and ligand are commercially available, bench stable, and highly cost-effective. The catalyst is applicable to both aryl- and heteroaryl-bromides as educts. A wide range of functional groups are tolerated and the aqueous reaction medium can be recycled. An application to a key intermediate associated with an active pharmaceutical ingredient (ponatinib) is discussed.
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