期刊
NATURE CATALYSIS
卷 2, 期 4, 页码 366-373出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41929-019-0231-9
关键词
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资金
- EPFL
- European Research Council under the European Union's Horizon 2020 research and innovation programme [681292]
- PECHouse3 project from the Swiss Federal Office of Energy [SI/500090-03]
- Strategic Japanese-Swiss Science and Technology Programme from the Swiss National Science Foundation [514259]
- Chinese Thousand Talents Program for Young Professionals
Photoelectrochemical cells are widely studied for solar energy conversion. However, they have rarely been used for the synthesis of high added-value organic molecules. Here we describe a strategy to use haematite, an abundant and robust photoanode, for non-directed arene C-H amination. Under illumination, the photogenerated holes in haematite oxidize electron-rich arenes to radical cations, which further react with azoles to give nitrogen heterocycles of medicinal interest. Unusual ortho selectivity was achieved, probably due to a hydrogen-bonding interaction between the substrates and the hexafluoroisopropanol co-solvent. The method exhibits broad scope and is successfully applied for the late-stage functionalization of several pharmaceutical molecules.
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