期刊
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
卷 316, 期 4, 页码 F693-F702出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajprenal.00486.2018
关键词
ASL; BOLD; diffusion; kidney; MRI
资金
- Swedish Research Council for Medicine and Health
- Swedish Diabetes Foundation
- Swedish Child Diabetes Foundation
- Family Ernfors Foundation
- Selander Foundation
- Olga Jonsson Foundation
- Region Uppsala
- Avtal om Lakarutbildning och Forskning funding Uppsala University Hospital
- Royal Society
- MRC [MR/M009122/1] Funding Source: UKRI
Noninvasive methods of magnetic resonance imaging (MRI) can quantify parameters of kidney function. The main purpose of this study was to determine baseline values of such parameters in healthy volunteers. In 28 healthy volunteers (15 women and 13 men), arterial spin labeling to estimate regional renal perfusion, blood oxygen level-dependent transverse relaxation rate (R-2*) to estimate oxygenation, and apparent diffusion coefficient (ADC), true diffusion (D), and longitudinal relaxation time (T-1) to estimate tissue properties were determined bilaterally in the cortex and outer and inner medulla. Additionally, phase-contrast MRI was applied in the renal arteries to quantify total renal blood flow. The results demonstrated profound gradients of perfusion, ADC, and D with highest values in the kidney cortex and a decrease towards the inner medulla. R-2* and T-1 were lowest in kidney cortex and increased towards the inner medulla. Total renal blood flow correlated with body surface area, body mass index, and renal volume. Similar patterns in all investigated parameters were observed in women and men. In conclusion, noninvasive MRI provides useful tools to evaluate intrarenal differences in blood flow, perfusion, diffusion, oxygenation, and structural properties of the kidney tissue. As such, this experimental approach has the potential to advance our present understanding regarding normal physiology and the pathological processes associated with acute and chronic kidney disease.
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