期刊
NANOSCALE
卷 11, 期 14, 页码 6602-6609出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nr01024f
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资金
- National Key Research and Development Program of China [2016YFA0203103]
- National Natural Science Foundation of China [31871012, 91543204, 91643204]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB14030401]
- Science and Technology Major Project of Shandong Province [2016GSF117033]
- Natural Science Foundation of Shandong Province [ZR2018MC004]
Research on nanoparticle (NP)-cell interactions has been extensively carried out in dilute cell cultures, where NPs are heavily internalized by cells. However, it is not known whether the findings from cell culture studies are still true in tissues where cells are tightly packed. Here, we show experimentally and theoretically that when cells are tightly packed, cellular uptake is strongly hindered. When simultaneously encountering two adjacent cells as is often the case in tissues, adhesion, bending and protrusion of at least two membranes from these cells generate complicated energy contributions that cause trapping of NPs at cell junctions with impeded uptake.
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