期刊
MARINE DRUGS
卷 15, 期 3, 页码 -出版社
MDPI AG
DOI: 10.3390/md15030028
关键词
natural products; secondary metabolism; structure elucidation; biological activity; biosynthesis; chemical synthesis
资金
- NSFC [21602152, 81403036]
- Shandong Provincial Natural Science Foundation [ZR2016BB01, ZR2014HM048]
- Shandong Provincial Key Research and Development Program [2016GSF202002]
- Shandong Provincial Medical Science and Technology Development Project [2013WS0321]
- Taian Science and Technology Development Project [2016NS1214]
- Shandong Provincial Education Department Project [J15LM56]
- National Undergraduate Training Program for Innovation and Entrepreneurship [201610439263]
- Taishan Medical University High-level Development Project [2015GCC15]
Polar organisms have been found to develop unique defences against the extreme environment environment, leading to the biosynthesis of novel molecules with diverse bioactivities. This review covers the 219 novel natural products described since 2001, from the Arctic and the Antarctic microoganisms, lichen, moss and marine faunas. The structures of the new compounds and details of the source organism, along with any relevant biological activities are presented. Where reported, synthetic and biosynthetic studies on the polar metabolites have also been included.
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