期刊
MARINE DRUGS
卷 15, 期 12, 页码 -出版社
MDPI AG
DOI: 10.3390/md15120379
关键词
Conus pulicarius; steroidal glycoside; cholesterol sulfate; cytotoxicity; leukemia
资金
- Korea Institute of Ocean Science and Technology
- Ministry of Oceans and Fisheries, Republic of Korea
Three new sulfated steroidal glycosides (3-5), along with known cholesterol derivatives (1,2), were isolated from the visceral extract of the cone snail Conus pulicarius. The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The three new compounds exhibited significant in vitro cytotoxicity (GI(50) values down to 0.49 mu M) against the K562 human leukemia cell line.
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