期刊
MARINE DRUGS
卷 15, 期 1, 页码 -出版社
MDPI AG
DOI: 10.3390/md15010016
关键词
bis(indole) alkaloid; Spongosorites; antibacterial; pancreatic cancer
资金
- National Institutes of Health [R21 AI078376, R33 AI105977, RO1CA093455]
- Harbor Branch Oceanographic Institute Foundation
A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines.
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