期刊
MARINE DRUGS
卷 15, 期 5, 页码 -出版社
MDPI AG
DOI: 10.3390/md15050137
关键词
endophytic fungus; Penicillium sp.; secondary metabolites; antimicrobial activity
资金
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
- Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02]
- Taishan Scholar Program from Shandong Province
Three new indolediterpenoids, namely, 22-hydroxylshearinine F (1), 6-hydroxylpaspalinine (2), and 7-O-acetylemindole SB (3), along with eight related known analogs (4-11), were isolated from the sea-anemone-derived fungus Penicillium sp. AS-79. The structures and relative configurations of these compounds were determined by a detailed interpretation of the spectroscopic data, and their absolute configurations were determined by ECD calculations (1 and 2) and single-crystal X-ray diffraction (3). Some of these compounds exhibited prominent activity against aquatic and human pathogenic microbes.
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