期刊
JOURNAL OF TISSUE ENGINEERING
卷 10, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/2041731419839846
关键词
Gut bioengineering; stem cells; organoids; gut repair; pharmaceutical research; lab on a chip
资金
- Nanjing Science and Technology Development Project [201803051]
- Innovation Project of Military Medicine [16CXZ007]
- Key Project of Jiangsu Social Development [BE2016752, BE2017722]
- National Major Scientific and Technological Special Project for Significant New Drugs Development [2018ZX09J18111-04]
The gastrointestinal (GI) tract has a diverse set of physiological functions, including peristalsis, immune defense, and nutrient absorptions. These functions are mediated by various intestinal cells such as epithelial cells, interstitial cells, smooth muscle cells, and neurocytes. The loss or dysfunction of specific cells directly results in GI disease, while supplementation of normal cells promotes gut healing. Gut bioengineering has been developing for this purpose to reconstruct the damaged tissues. Moreover, GI tract provides an accessible route for drug delivery, but the collateral damages induced by side effects cannot be ignored. Bioengineered intestinal tissues provide three-dimensional platforms that mimic the in vivo environment to study drug functions. Given the importance of gut bioengineering in current research, in this review, we summarize the advances in the technologies of gut bioengineering and their applications. We were able to identify several ground-breaking discoveries in our review, while more work is needed to promote the clinical translation of gut bioengineering.
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