期刊
FEMS YEAST RESEARCH
卷 19, 期 3, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsyr/foz032
关键词
pathogen; Candida albicans; Candida glabrata; ecology; Candida tropicalis; wild yeasts
资金
- National Science Foundation [DEB-1253634, DEB-1442148, DGE-1256259]
- Lakeshore Nature Preserve Student Engagement Grants
- DOE Great Lakes Bioenergy Research Center (DOE Office of Science BER) [DE-SC0018409]
- Predoctoral Training Program in Genetics - National Institutes of Health [5T32GM007133]
- Pew Charitable Trusts
- Vilas Trust Estate
Budding yeasts are distributed across a wide range of habitats, including as human commensals. However, under some conditions, these commensals can cause superficial, invasive, and even lethal infections. Despite their importance to human health, little is known about the ecology of these opportunistic pathogens, aside from their associations with mammals and clinical environments. During a survey of approximately 1000 non-clinical samples across the United States of America, we isolated 54 strains of budding yeast species considered opportunistic pathogens, including Candida albicans and Candida (Nakaseomyces) glabrata. We found that, as a group, pathogenic yeasts were positively associated with fruits and soil environments, whereas the species Pichia kudriavzevii (syn. Candida krusei syn. Issatchenkia orientalis) had a significant association with plants. Of the four species that cause 95% of candidiasis, we found a positive association with soil. These results suggest that pathogenic yeast ecology is more complex and diverse than is currently appreciated and raises the possibility that these additional environments could be a point of contact for human infections.
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