期刊
MAGNETIC RESONANCE IN MEDICINE
卷 79, 期 3, 页码 1241-1250出版社
WILEY
DOI: 10.1002/mrm.26788
关键词
3T; sLASER; PRESS; FAST(EST)MAP; chemical shift displacement; linewidth
资金
- Minnesota Partnership for Biotechnology and Medical Genomics
- NIH [R01 NS080816, P41 EB015894, P30 NS076408, R01 AG040042]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [P41EB015894] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [U01NS100620, P30NS076408, R01NS080816] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG040042, P50AG016574, RF1AG057547] Funding Source: NIH RePORTER
PurposeTo investigate the utility of an advanced magnetic resonance spectroscopy (MRS) protocol in the clinical setting, and to compare the localization accuracy, spectral quality, and quantification repeatability between this advanced and the conventional vendor-provided MRS protocol on a clinical 3T platform. MethodsProton spectra were measured from the posterior cingulate cortices in 30 healthy elderly subjects by clinical MR technologists using a vendor-provided (point resolved spectroscopy with advanced 3D gradient-echo B-0 shimming) and an advanced (semi-LASER with FAST(EST)MAP shimming) protocol, in random order. Spectra were quantified with LCModel using standard pipelines for the clinical and research settings, respectively. ResultsThe advanced protocol outperformed the vendor-provided protocol in localization accuracy (chemical-shift-displacement error: 2.0%/ppm, semi-LASER versus 11.6%/ppm, point resolved spectroscopy), spectral quality (water linewidth: 6.11.8Hz, FAST(EST)MAP versus 10.5 +/- 3.7Hz, 3D gradient echo; P<7e-6; residual water: 0.08 +/- 0.12%, VAPOR versus 0.45 +/- 0.50%, WET; P<2e-5) and within-session repeatability of metabolite concentrations, particularly of low signal-to-noise ratio data with two to eight averages (test-retest coefficients of variance of metabolite concentrations, P<0.01). Concentrations of J-coupled metabolites such as -aminobutyric acid and glutamate were biased when using the default pipeline with simulated macromolecules. ConclusionsThe quality of MRS data can be improved using advanced acquisition and analysis protocols on standard 3T hardware in the clinical setting, which can facilitate robust applications in central nervous system diseases. Magn Reson Med 79:1241-1250, 2018. (c) 2017 International Society for Magnetic Resonance in Medicine.
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