期刊
MAGNETIC RESONANCE IN MEDICINE
卷 79, 期 4, 页码 2142-2148出版社
WILEY
DOI: 10.1002/mrm.26852
关键词
spinal cord; reduced FOV; T-1 mapping; reproducibility; inversion Recovery
资金
- UK MS Society
- UCL-UCLH Biomedical Research Centre
- Horizon2020-EU3.1 CDS-QUAMRI [634541]
- Guarantors of Brain Project
- MRC [MR/J500422/1, MR/J01107X/1]
- NIHR BRC UCLH/UCL High Impact Initiative [BW.mn.BRC10269]
- EPSRC [EP/H046410/1, EP/J020990/1, EP/K005278]
- Wings for Life
- Spinal Research
- Craig H. Neilsen Foundation
- [EPSRC EP/I027084/1]
- [ISRT IMG006]
- EPSRC [EP/I027084/1, EP/M020533/1, EP/N018702/1, EP/J020990/1, EP/H046410/1, EP/G007748/1] Funding Source: UKRI
- MRC [MR/M009106/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/H046410/1, EP/N018702/1, EP/G007748/1, EP/J020990/1] Funding Source: researchfish
- Medical Research Council [MR/M009106/1, MR/J01107X/1] Funding Source: researchfish
PurposeTo develop a fast and robust method for measuring T-1 in the whole cervical spinal cord in vivo, and to assess its reproducibility. MethodsA spatially nonselective adiabatic inversion pulse is combined with zonally oblique-magnified multislice echo-planar imaging to produce a reduced field-of-view inversion-recovery echo-planar imaging protocol. Multi- inversion time data are obtained by cycling slice order throughout sequence repetitions. Measurement of T-1 is performed using 12 inversion times for a total protocol duration of 7min. Reproducibility of regional T-1 estimates is assessed in a scan-rescan experiment on five heathy subjects. ResultsRegional mean (standard deviation) T-1 was: 1108.5 (77.2) ms for left lateral column, 1110.1 (+/- 83.2) ms for right lateral column, 1150.4 (+/- 102.6) ms for dorsal column, and 1136.4 (+/- 90.8) ms for gray matter. Regional T-1 estimates showed good correlation between sessions (Pearson correlation coefficient=0.89 (P value<0.01); mean difference=2 ms, 95% confidence interval +/- 20 ms); and high reproducibility (intersession coefficient of variation approximately 1% in all the regions considered, intraclass correlation coefficient=0.88 (P value<0.01, confidence interval 0.71-0.95)). ConclusionsT(1) estimates in the cervical spinal cord are reproducible using inversion-recovery zonally oblique-magnified multislice echo-planar imaging. The short acquisition time and large coverage of this method paves the way for accurate T-1 mapping for various spinal cord pathologies. Magn Reson Med 79:2142-2148, 2018. (c) 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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