4.2 Article

Unsaturated cryptophanes: Toward dual PHIP/hyperpolarised xenon sensors

期刊

MAGNETIC RESONANCE IN CHEMISTRY
卷 56, 期 7, 页码 672-678

出版社

WILEY
DOI: 10.1002/mrc.4691

关键词

-

向作者/读者索取更多资源

Cryptophanes, cage-molecules constituted of aromatic bowls, are now well recognised as powerful xenon hosts in Xe-129 NMR-based biosensing. In the quest of a dual probe that can be addressed only by NMR, we have studied three cryptophanes bearing a tether with an unsaturated bond. The idea behind this is to build probes that can be detected both via hyperpolarised Xe-129 NMR and para-hydrogen induced polarisation H-1 NMR. Only two of the three cryptophanes experience a sufficiently fast hydrogenation enabling the para-hydrogen induced polarisation effect. Although the in-out xenon exchange properties are maintained after hydrogenation, the chemical shift of xenon encaged in these two cryptophanes is not strikingly modified, which impedes safe discrimination of the native and hydrogenated states via Xe-129 NMR. However, a thorough examination of the hyperpolarised H-1 spectra reveals some interesting features for the catalytic process and gives us clues for the design of doubly smart H-1/Xe-129 NMR-based biosensors.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.2
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据