期刊
MAGNETIC RESONANCE IMAGING
卷 36, 期 -, 页码 175-179出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2016.10.005
关键词
Breast lesions; Intravoxel incoherent motion; Diffusion-weighted imaging; Dynamic contrast-enhanced magnetic resonance imaging
Purpose: To investigate the value of use of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) as an adjunct to dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to distinguish benign from malignant breast lesions. Materials and methods: Retrospective analysis of data pertaining to 117 patients with breast lesions who underwent DCE-MRI and IVIM-DWI examination with 3.0 T MRI was conducted. A total of 128 lesions were pathologically confirmed (47 benign and 81 malignant). Between-group differences in DCE-MRI parameters (Morphology, enhancement pattern, maximum slope of increase (MSI) and time-signal curve (TIC) type) and IVIM-DWI parameters (f value, D value and D* value) were assessed. Multivariate logistic regression was performed to identify variables that distinguished benign from malignant breast lesions. The diagnostic performance of DCE-MRI and DCE-MRI plus IVIM-DWI, to distinguish benign from malignant breast lesions, was evaluated using pathology results as the gold standard. Results: Lesion morphology, MSI, and TIC type (P < 0.05), but not the enhancement pattern (P > 0.05), were significantly different between the benign and malignant groups. The f (8.53 +/- 2.14) and D* (7.64 +/- 2.07) values in the malignant group were significantly higher than those in the benign group (7.68 +/- 1.97 and 6.83 +/- 2.13, respectively), while the D value (0.99 +/- 0.22) was significantly lower than that (1.34 +/- 0.17) in the benign group (P < 0.05 for all). On logistic regression analysis, the sensitivity, specificity and accuracy of DCE-MRI were 90.1%, 70.2% and 82.8% respectively; the corresponding figures for the combination of IVIM-DWI and DCE-MRI were 88.8%, 85.1%, and 87.5%respectively. Conclusion: IVIM-DWI method as an adjunct to DCE-MRI can improve the specificity and accuracy in differential diagnosis of benign and malignant lesions of breast. (C) 2016 Elsevier Inc. All rights reserved.
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