期刊
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
卷 8, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s40164-019-0133-1
关键词
MDS; Venetoclax; Combination therapy; Hematotoxicity; HMA failure
资金
- Hans-und-Klementia- Langmatz-Stiftung
- DGHO/GMIHO
- Deutsche Jose Carreras Leukamie-Stiftung/DGHO
- Deutsche Jose Carreras Leukamie-Stiftung [DJCLS R 14/16, DJCLS R 12/22, DJCLS 21R/2016]
- German Research Foundation [FOR 2033, Go 713/2-1, SFB 1243]
- Deutsche Konsortium fur translationale Krebsforschung (DKTK) of the German Cancer Center (DKFZ)
- Max Eder-Program grant from the Deutsche Krebshilfe [111738]
- Else Kroner Fresenius Stiftung from the Deutsche Forschungsgemeinschaft [2014_A185, DFG FOR 2036]
Patients with Myelodysplastic Syndromes (MDS) and secondary Acute Myeloid Leukemia (sAML) have a very poor prognosis after failure of hypomethylating agents (HMA). Stem cell transplantation is the only effective salvage therapy, for which only a limited number of patients are eligible due to age and comorbidity. Combination therapy of venetoclax and azacitidine (5-AZA) seems to be a promising approach in myeloid malignancies, but data from patients with HMA failure are lacking. Furthermore, a considerable concern of combination regimens in elderly AML and MDS patients is the toxicity on the remaining healthy hematopoiesis. Here, we report in vitro data showing the impact of venetoclax and 5-AZA, alone or in combination, in a larger cohort of MDS/sAML patients (n = 21), even after HMA failure (n = 13). We especially focused on the effects on healthy hematopoiesis and the impact on colony forming capacity as a parameter for long-term effects. To the best of our knowledge, we show for the first time that venetoclax in combination with capped dose of 5-AZA targets cell malignancies, while sparing healthy hematopoiesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据