期刊
MACROMOLECULES
卷 50, 期 3, 页码 1085-1089出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.macromol.6b02166
关键词
-
资金
- NSF [DMR-1309414, DMR-1611497]
- Direct For Mathematical & Physical Scien [1611497] Funding Source: National Science Foundation
- Division Of Materials Research [1611497] Funding Source: National Science Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1309414] Funding Source: National Science Foundation
Hyaluronic acid (HA) is a charged polysaccharide with an intrinsic stiffness intermediate between flexible and semiflexible polymers. To investigate the interplay of that stiffness with solution electrostatic interactions, we perform single-molecule stretching measurements on HA over 4 decades of monovalent ionic strength. We observe a low force (<1 pN), salt-sensitive swollen (Pincus) elasticity regime and use a rescaling analysis to show that the data are inconsistent with a quadratic, OSF dependence of the chain's persistence length on the solution Debye length. Instead, the persistence length varies nearly linearly with Debye length. The chain's high-force (1-10 pN) elastic response deviates from exact worm-like chain models, even after accounting for electrostatic effects; the failure of these models emphasizes the utility of both low-force data and a robust scaling-based analysis scheme. Our results give insight into electrostatic effects in an intermediately stiff polymer as well as demonstrating elastic phenomena that could impact understanding of HA's mechanobiological roles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据