4.3 Article

Silicone rubber with mussel-inspired adhesive coatings for enhancing antifouling property and blood compatibility

期刊

MACROMOLECULAR RESEARCH
卷 25, 期 8, 页码 841-848

出版社

SPRINGER
DOI: 10.1007/s13233-017-5092-y

关键词

silicone rubber; hyaluronic acid; poly(ethylene glycol); dopamine; antifouling; blood compatibility

资金

  1. Basic Science Research Program through the National Research Foundation of Korea [2017R1A2B3011121]
  2. Cell Regeneration Program through the National Research Foundation of Korea [2012M2A9C6049717]
  3. Bio & Medical Technology Development Program through the National Research Foundation of Korea [2014M3A9D3033887]
  4. KIST Program through the National Research Foundation of Korea [2E25260]
  5. National Research Council of Science & Technology grant - Ministry of Science, ICT & Future Planning (MSIP), Republic of Korea [CAP-12-05-KFRI]
  6. Ministry of Science, ICT & Future Planning, Republic of Korea [2E25260] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
  7. National Research Council of Science & Technology (NST), Republic of Korea [CAP-12-05-KFRI] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
  8. National Research Foundation of Korea [2017R1A2B3011121] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

Silicone rubber is widely used in various biomedical fields. However, the silicone surface is known to cause biofouling and thrombosis issues due to its higher hydrophobic property. In this study, to improve its antifouling property and blood compatibility, silicone rubber was modified by coating of hyaluronic acid (HA) or poly(ethylene glycol) (PEG). To enhance adhesive property of HA and PEG on the silicone surface, HA and PEG were modified by introducing the amino groups of dopamine (DA) to the carboxyl group of each polymer. The modified HA (HA-DA) and PEG (PEG-DA) were confirmed by 1H nuclear magnetic resonance (NMR) and the coated surfaces were characterized with contact angle, X-ray photoelectron spectroscopy (XPS), and micro-bicinchoninic acid (micro-BCA) analyses. To compare antifouling property and blood compatibility, adsorbed proteins, adhered platelets, and anticoagulation on the modified surfaces were evaluated by fluorescence microscopy, scanning electron microscopy, and activated partial thromboplastin time (APTT) assay, respectively. The property of cell adhesion on the modified surface was evaluated by NIH 3T3 fibroblast as a model cell system. Protein, platelet, and fibroblast showed low adsorption and adhesion on the modified silicone rubber surfaces compared to the unmodified one. Especially, the third coated silicone rubber surfaces were found to strongly resist protein adsorption as well as platelet and fibroblast adhesion. These results indicated that the antifouling property and blood compatibility were enhanced significantly on HA-DA and PEG-DA immobilized silicone rubbers. Therefore, these modified silicone rubbers can be used in various biomedical applications.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据