期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 38, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201700018
关键词
gelatin; hydrogels; ionic coordination; self-healing; UPy
资金
- National Natural Science Foundation of China [21474032]
- Natural Science Foundation of Guangdong Province [2016A030311031]
Self-healing hydrogels have been studied by many researchers via multiple cross-linking approaches including physical and chemical interactions. It is an interesting project in multifunctional hydrogel exploration that a water soluble polymer matrix is cross-linked by combining the ionic coordination and the multiple hydrogen bonds to fabricate self-healing hydrogels with injectable property. This study introduces a general procedure of preparing the hydrogels (termed gelatin-UPy-Fe) cross-linked by both ionic coordination of Fe3+ and carboxyl group from the gelatin and the quadruple hydrogen bonding interaction from the ureido-pyrimidinone (UPy) dimers. The gelatin-UPy-Fe hydrogels possess an excellent self-healing property. The effects of the ionic coordination of Fe3+ and quadruple hydrogen bonding of UPy on the formation and mechanical behavior of the prepared hydrogels are investigated. In vitro drug release of the gelatin-UPy-Fe hydrogels is also observed, giving an intriguing glimpse into possible biological applications.
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