期刊
RUSSIAN CHEMICAL BULLETIN
卷 68, 期 1, 页码 55-63出版社
SPRINGER
DOI: 10.1007/s11172-019-2415-5
关键词
polyhydroxy-1,4-naphthoquinones; naphthazarins; pigments of sea urchins; naphthopurpurin; mompain; isomompain; ethylspinazarin; antioxidants; O-methylation; trimethyl orthoacetate
资金
- Russian Academy of Sciences [18-4-021]
Trimethyl orthoacetate was found to be a convenient reagent for methylation of the beta-OH groups of (poly)hydroxynaphthazarins. The substrates bearing one beta-OH group react with MeC(OMe)(3) to give the corresponding methoxy derivatives in 79-89% yields. Depending on the reaction conditions, methylation of substrates with two beta-OH groups on the different and the same rings affords either the corresponding mono-O-methylated (43-70%) or di-Omethylated (71-78%) derivatives. Trimethyl orthoacetate offers a good alternative to CH2N2 in the preparative synthesis of O-methylated (poly)hydroxynaphthazarin derivatives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据