期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 38, 期 24, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201700500
关键词
amidation; sequence-defined polymers; thioacrylate; thiolactone
资金
- European Union's Horizon 2020 research and innovation program under Marie Sklodowska-Curie [642083]
A strategy for the synthesis of sequence-defined oligomers using a selective side-group insertion approach making use of thiophenol-catalyzed amidation reactions is herein reported. In this context, a new thiolactone-based, multistep, iterative protocol is designed, utilizing thioacrylates in combination with solid-phase synthesis for step-by-step growth, resulting in sequence-defined oligomers. Sequence definition and structure variation are introduced by substituting the thioacrylate side groups with a wide variety of amines. The step-by-step growth of the oligomers is followed by liquid chromatography-mass spectrometry and high-resolution mass spectroscopy to determine both conversion and purity.
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