期刊
MACROMOLECULAR BIOSCIENCE
卷 17, 期 11, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201700201
关键词
aptamer; endothelial cell; hydrogel; RGD peptide; vascular endothelial growth factor
资金
- U.S. National Science Foundation [DMR-1332351]
- National Heart, Lung, Blood Institute of the National Institutes of Health [HL122311]
- Talent Invitation Program of Dalian [TPDL2015]
Synthetic molecular libraries hold great potential to advance the biomaterial development. However, little effort is made to integrate molecules with molecular recognition abilities selected from different libraries into a single biomolecular material. The purpose of this work is to incorporate peptides and nucleic acid aptamers into a porous hydrogel to develop a dual-functional biomaterial. The data show that an anti-integrin peptide can promote the attachment and growth of endothelial cells in a 3D porous poly(ethylene glycol) hydrogel and an antivascular endothelial growth factor aptamer can sequester and release VEGF of high bioactivity. Importantly, the dual-functional porous hydrogel enhances the growth and survival of endothelial cells. This work demonstrates that molecules selected from different synthetic libraries can be integrated into one system for the development of novel biomaterials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据