期刊
CLINICAL AND TRANSLATIONAL MEDICINE
卷 8, 期 -, 页码 -出版社
JOHN WILEY & SONS LTD
DOI: 10.1186/s40169-019-0230-0
关键词
Epigenome; Liver cancer; HCC; DNA methylation; Histone methylation; ncRNA
资金
- National Research Foundation Cancer Science Institute of Singapore RCE Main Grant
- Ministry of Education Academic Research Fund (MOE AcRF Tier 2) [MOE2015-T2-2-126]
- Ministry of Education Academic Research Fund (MOE AcRF Seed Fund Grant) [T1-BSRG 2014-05]
- NMRC Translational and Clinical Research (TCR) Flagship Programme [NMRC/TCR/015-NCC/2016]
In recent years, large scale genomics and genome-wide studies using comprehensive genomic tools have reshaped our understanding of cancer evolution and heterogeneity. Hepatocellular carcinoma, being one of the most deadly cancers in the world has been well established as a disease of the genome that harbours a multitude of genetic and epigenetic aberrations during the process of liver carcinogenesis. As such, in depth understanding of the cancer epigenetics in cancer specimens and biopsy can be useful in clinical settings for molecular subclassification, prognosis, and prediction of therapeutic responses. In this review, we present a concise discussion on recent progress in the field of liver cancer epigenetics and some of the current works that contribute to the progress of liver cancer therapeutics.
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