期刊
MACROMOLECULAR BIOSCIENCE
卷 17, 期 6, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201600472
关键词
bioprinting; hydrogels; mechanical properties; tissue engineering
资金
- EPSRC
- MRC Centre for Doctoral Training in Regenerative Medicine
- BBSRC [BB/R012415/1] Funding Source: UKRI
- EPSRC [EP/N006615/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/R012415/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [1378727, EP/N006615/1] Funding Source: researchfish
The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combination of optimal biological and mechanical properties in bioprinted constructs. Here, a novel bioprinting method that utilizes core-shell cell-laden strands with a mechanically robust shell and an extracellular matrix-like core has been developed. Cells encapsulated in the strands demonstrate high cell viability and tissue-like functions during cultivation. This process of bioprinting using core-shell strands with optimal biochemical and biomechanical properties represents a new strategy for fabricating functional human tissues and organs.
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