期刊
MACROMOLECULAR BIOSCIENCE
卷 17, 期 9, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201700090
关键词
acne; antibiotic resistance; minimum inhibitory concentration; Propionibacterium acnes
资金
- National Science Foundation, Division of Materials Research, Polymers Program [DMR-1206259]
- Polymers/Biomaterials Programs [DMR-1608022]
- School of Engineering Foundation
- Public Health Service Grant from the National Institute of Allergy and Infectious Disease [AI-19146]
- Veterans Administration Medical Research Fund [I01 BX000477]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1608022] Funding Source: National Science Foundation
A preliminary study is reported for a polycation antimicrobial peptide (AMP) mimic against Propionibacterium acnes, which is associated with acne vulgaris, a common skin condition. Antibiotics are commonly used against P. acnes but buildup of resistance is well-known. Worse, antibiotic regimens build up resistance for more sensitive bacteria such as Staphylococcus epidermidis. The polycation AMP mimic C12-50, 1, is chosen for the present study as it has been previously shown to have high antimicrobial effectiveness. This study reports that C12-50 is active against P. acnes (strain ATCC 6919) with a minimum inhibitory concentration (MIC) of 6.3 mu g mL(-1). To monitor resistance build-up ten passages are conducted with C12-50 against P. acnes. The MIC remains constant with no resistance buildup. Parallel studies with erythromycin confirm previously reported resistance buildup. The results point to a promising pathway to applications for polycation AMP mimics against P. acnes.
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