期刊
MACROMOLECULAR BIOSCIENCE
卷 17, 期 8, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201700096
关键词
nanostructures; peptide amphiphiles; polyamines; self-assembly
资金
- university of Nebraska Medical Center
- NIH-COBRE [5P20GM103480]
- UNMC High School Alliance program
- Sherwood Foundation
- NIGMS-NIH [GM103427]
- Nebraska Research Initiative (NRI)
- University of Nebraska Foundation
The ability to tune supramolecular properties such as size, morphology, or metabolic stability is of paramount importance in the field of supramolecular chemistry. Peptide amphiphiles (PAs) are a family of functional self-assembling biomaterials that have garnered widespread attention due to their broad applicability in medicine. PAs are generally comprised of an amino acid sequence connected to lipid tail(s) allowing them to self-assemble into supramolecular structures with diverse morphologies. Herein, this study describes the synthesis of a new class of polyamine-based hybrid PAs (PPAs) as novel self-assembling systems. The described mole-cules possess diverse polyamine head groups with the goal of tuning physicochemical properties. The findings indicate that small changes in the polyamine head groups result in altered PPA morphologies (nanofibers, micelles, nanoworms). The PPAs present a wide range of physicochemical characteristics, show superior resistance to aggregation, a diverse metabolic profile, and varied assembling kinetics. Most of the PPAs do not show toxicity in the human cells lines evaluated. The PPAs described herein hold promising potential as a safe and nontoxic option for drug delivery, targeting, and tissue engineering applications.
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