期刊
MABS
卷 9, 期 6, 页码 927-944出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19420862.2017.1332553
关键词
Antibody; celiac disease; cis; eosinophilic esophagitis; humanized; interleukin-15; IL-15; trans
资金
- Swiss National Science Foundation [32003B_135665, 32003B_160115/1, 310030_166473]
- Swiss National Science Foundation (SNF) [32003B_135665] Funding Source: Swiss National Science Foundation (SNF)
Interleukin-15 (IL-15) is a critical regulator of immune responses, especially at mucosal interfaces within the gastro-intestinal tract. Here, we describe the discovery and characterization of a humanized antibody to IL-15. Data from its epitope and mode of action, cell biology and primate pharmacology, as well as translational studies in human samples and in vivo proof-of-concept experiments in mouse models demonstrate the therapeutic potential of this new antibody targeting IL-15 for refractory celiac disease and eosinophilic esophagitis.
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