期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 12, 页码 3225-3231出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob00178f
关键词
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资金
- Polish National Science Centre [DEC-2015/16/S/ST5/00440]
- Foundation for Polish Science [TEAM/2017-4/38]
Asymmetric total synthesis of (+)-asenapine, an atypical antipsychotic drug, used for treating schizophrenia and acute mania associated with bipolar disorder, is reported. The key steps are the organocatalytic Michael addition of aldehydes to trans-nitroalkenes and subsequent reductive cyclization.
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