期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 12, 页码 3113-3117出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob00080a
关键词
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资金
- Deutsche Forschungsgemeinschaft [BE 4572/3-1, INST 268/281-1 FUGG]
- European Union, European Regional Development Fund
- Free State of Saxony, European Regional Development Fund
We report the hydrophobically-tagged Plk1 PBD inhibitor Poloxin-2HT+, which selectively degrades the tumor target Plk1 and induces apoptosis in human tumor cells with higher potency than the hydrophobically-tagged inhibitor Poloxin-2HT. Our data provide further evidence that hydrophobically tagged inhibitors of protein-protein interactions can target and destroy disease-relevant proteins.
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