期刊
MATHEMATICAL BIOSCIENCES AND ENGINEERING
卷 16, 期 1, 页码 320-337出版社
AMER INST MATHEMATICAL SCIENCES-AIMS
DOI: 10.3934/mbe.2019016
关键词
dynamic buffer capacity; two-compartment model; stochastic differential equations; numerical simulations
资金
- BioComp Research Unit at the University of Kaiserslautern (TUK)
The most aggressive tumor cells, which often reside in a hypoxic environment, can release vast amounts of lactate and protons via monocarboxylate transporters (MCTs). This additional proton efflux exacerbates extracellular acidification and supports the formation of a hostile environment. In the present study we propose a novel, data-based model for this proton-coupled lactate transport in cancer cells. The mathematical settings involve systems coupling nonlinear ordinary and stochastic differential equations describing the dynamics of intra-and extracellular proton and lactate concentrations. The data involve time series of intracellular proton concentrations of normoxic and hypoxic MCF-7 breast cancer cells. The good agreement of our final model with the data suggests the existence of proton pools near the cell membrane, which can be controlled by intracellular and extracellular carbonic anhydrases to drive proton-coupled lactate transport across the plasma membrane of hypoxic cancer cells.
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