期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 7, 期 18, 页码 3027-3033出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb00361d
关键词
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资金
- National Key R&D Program of China [2018YFF0215404]
- National Natural Science Foundation of China [11727810, 21606149]
- Shanghai Natural Science Foundation [18ZR1411300]
A luminescent terbium metal-organic framework (Tb-MOF) was prepared using Tb3+ as metal ions and a boronic acid ligand (3,5-dicarboxybenzeneboronic acid) as linkers, which was successfully employed for the detection and scavenging of reactive oxygen species (ROS) in living cells. After the formation of the Tb-MOF, the luminescence of Tb3+ is sensitized by the organic linkers. In addition, the functionalization of boronic acid groups in the channels of MOFs also enhances the luminescence of Tb3+ ions through the antenna effect by adjusting the energy level of the ligand. In addition, the free boronic acid groups act as active sites and react with ROS due to a rapid nucleophilic addition reaction, which leads to the luminescence quenching of Tb-MOF. On the basis of these findings, the boronic acid-functionalized Tb-MOF can be used as an excellent ROS scavenger and a nanoprobe for highly selective and sensitive detection of ROS in living cells.
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