期刊
LIVER INTERNATIONAL
卷 37, 期 7, 页码 968-973出版社
WILEY
DOI: 10.1111/liv.13430
关键词
alcoholic liver disease; interleukin 1; interleukin 1 receptor antagonist; liver regeneration
资金
- National Institute on Alcohol Abuse and Alcoholism (NIAAA) [U01AA021907, U01AA021902, F31AA025545]
Background & Aims: Inflammation and impaired hepatocyte regeneration contribute to liver failure in alcoholic hepatitis (AH). Interleukin (IL)-1 is a key inflammatory cytokine in the pathobiology of AH. The role of IL-1 in liver regeneration in the recovery phase of alcohol-induced liver injury is unknown. Methods: In this study, we tested IL-1 receptor antagonist to block IL-1 signalling in a mouse model of acute-on-chronic liver injury on liver inflammation and hepatocyte regeneration in AH. Results: We observed that inhibition of IL-1 signalling decreased liver inflammation and neutrophil infiltration, and resulted in enhanced regeneration of hepatocytes and increased rate of recovery from liver injury in AH. Conclusion: Our novel findings suggest that IL-1 drives sustained liver inflammation and impaired hepatocyte regeneration even after cessation of ethanol exposure.
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