期刊
CHINESE CLINICAL ONCOLOGY
卷 8, 期 2, 页码 -出版社
AME PUBLISHING COMPANY
DOI: 10.21037/cco.2019.03.02
关键词
Pancreatic cancer; tumor therapy; tumor microenvironment
类别
资金
- National Natural Science Foundation of China [81871923, 81802890, 81872242, 81502382, 81500461, 81761138045]
- State Key Laboratory of Oncogenes and Related Genes [91-17-24]
- Shanghai health and family planning commission foundation [201740105]
Pancreatic ductal adenocarcinoma (PDAC) is one of the most dangerous cancers, and the overall 5-year survival rate is only 8%. The microenvironment of PDAC, which promotes tumorigenesis, disease development and metastasis, consists of fibroblasts, immune cells, pancreatic stellate cells (PaSCs), adipocytes and extracellular matrix (ECM). Because the microenvironment is a part of the tumor, it is also an important target for PDAC treatment. Several therapeutic regimens targeting PDAC microenvironment factors or cells have been investigated, but the treatment effects were poor. More research on the physiological and pathological mechanisms and clinical treatment of PDAC is necessary.
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