期刊
ANALYTICAL METHODS
卷 11, 期 17, 页码 2333-2340出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ay00289h
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- CNPq
- CAPES
In this work, a simple method for the determination of 20 pharmaceuticals of different classes in drinking water using solid phase extraction (SPE) and ultra-high performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) was developed and validated. Different sorbents, solvents and elution volumes were evaluated. The optimized conditions of the extraction step were the Strata (TM)-X cartridge, samples without pH adjustment but with addition of 0.1% (w/v) of EDTA, eluting solvent 1% (v/v) acetic acid in acetonitrile/methanol 1 : 1 (v/v) and an elution volume of 1 mL. Recovery results were adequate ranging from 70 to 119%, with relative standard deviation (RSD) # 19%. The limits of quantification and detection of the method were from 0.01 to 0.1 mg L-1 and from 0.003 to 0.03 mg L-1, respectively, considered suitable for monitoring of these compounds in drinking water. The proposed method was successfully applied in real samples. Atenolol, carbamazepine and paracetamol were found in some samples at concentrations <= 0.027 mu g L-1.
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