期刊
LIFE SCIENCES
卷 170, 期 -, 页码 33-40出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2016.11.016
关键词
Satellite cells activation; Skeletal muscle; Endurance exercise
资金
- FAPESP [2016/18633-8, 2011/06815-0]
- CNPq [457358/2013-0, 407849/2013-0, 472090/2013-5]
- CAPES [88887.124164/2014-00]
- National Institute of Sciences and Technology in Obesity and Diabetes (INCT)
- Dean's Office for Research (NAP), University of Sao Paulo
- Dean's Office for Postgraduate Studies and Research of the Cruzeiro do Sul University [2014/33078017]
- Guggenheim Foundation [04/2008]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [11/06815-0] Funding Source: FAPESP
Although the requirement of satellite cells activation and expansion following injury, mechanical load or growth stimulus provoked by resistance exercise has been well established, their function in response to aerobic exercise adaptation remains unclear. A clear relationship between satellite cell expansion in fiber-type specific myosin heavy chain and aerobic performance has been related, independent of myonuclear accretion or muscle growth. However, the trigger for this activation process is not fully understood yet and it seems to be a multi-faceted and well-orchestrated process. Emerging in vitro studies suggest a role for metabolic pathways and oxygen availability for satellite cell activation, modulating the self-renewal potential and cell fate control. The goal of this review is to describe and discuss the current knowledge about the satellite cell activation and expansion in response to aerobic exercise adaptation in human and rodent models. Additionally, findings about the in vitro metabolic control, which seems be involved in the satellite cell activation and cell fate control, are presented and discussed. (C) 2016 Elsevier Inc. All rights reserved.
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