期刊
RSC ADVANCES
卷 9, 期 22, 页码 12667-12674出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra00800d
关键词
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资金
- Key Research and Development Program of Jiangsu Province [BE2017665]
- National Key Basic Research Program of China (973 Program) [2014CB965003]
- National Natural Science Foundation of China [31700831]
A new class of stimuli responsive drug delivery systems is emerging to establish new paradigms for enhancing therapeutic efficacy. To date, most electro-responsive systems rely on noble metal electrodes that likely cause the limitations for implantation applications. Herein, a graphene/polypyrrole composite electrode (GN-PPy-FL) was fabricated based on two-dimensional (2D) graphene (GN) film and conductive and biocompatible polypyrrole (PPy) nanoparticles loaded with a negative drug model of fluorescein sodium (FL) via chemical oxidation polymerization. The conductive composite electrode was utilized as a drug carrier to realize the electrically controlled release of the FL. The release rate from conductive nanoparticles can be controlled by the applied voltages. The study provides a multi-stimuli responsive drug release system, demonstrating the potential applications of the controlled release of various drugs, peptides or proteins.
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