期刊
LEUKEMIA RESEARCH
卷 54, 期 -, 页码 66-72出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2017.01.018
关键词
CLL; Oxidative stress; TNF-alpha polymorphism
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [11141018]
The aim of this study was to examine the association of TNF-alpha-308G/A polymorphism with CLL and influence on oxidative stress parameters.Significant difference in the genotype and allele distribution was obtained in TNFA subgroup of patients.Significantly higher GPx activity and TBARS and lower catalase activity were detected in CLL.Significantly higher catalase and lower GPx activities were detected in PBMC of TNFG compared to TNFA subgroup, while TBARS were higher in TNFA.Oxidative stress in CLL patients highly correlates with the presence of TNFA subgroup. Increased TBARS, GPx and decreased catalase activity are associated with TNF-alpha-308A allele containing genotypes. (C) 2017 Elsevier Ltd. All rights reserved.
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