期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 76, 期 11, 页码 2111-2132出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03056-x
关键词
Endometriosis; Cytokine; Anti-inflammatory; IL-10; TGF-; Endometrial stromal cells; Macrophage; T cells; NK cells
资金
- National Natural Science Foundation of China (NSFC) [91542108, 81471513, 31671200, 81601354, 31600735, 81571509]
- Shanghai Rising-Star Program [16QA1400800]
- NPFPC Key Laboratory of Reproduction Regulation [CX2017-2]
- Program for Zhuoxue of Fudan University
- National Science Foundation of Jiangsu Province [BK20160128]
- Fundamental Research Funds for the Central Universities [021414380180]
- Open Project Program of Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases (CN) [14DZ2271700]
Although the pathogenesis of endometriosis is notfully understood, it is often considered to be an inflammatory disease. An increasing number of studies suggest that differential expression of anti-inflammatory cytokines (e.g., interleukin-4 and -10, and transforming growth factor-1) occurs in women with endometriosis, including in serum, peritoneal fluid and ectopic lesions. These anti-inflammatory cytokines also have indispensable roles in the progression of endometriosis, including by promoting survival, growth, invasion, differentiation, angiogenesis, and immune escape of the endometriotic lesions. In this review, we provide an overview of the expression, origin, function and regulation of anti-inflammatory cytokines in endometriosis, with brief discussion and perspectives on their future clinical implications in the diagnosis and therapy of the disease.
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