期刊
LEUKEMIA & LYMPHOMA
卷 58, 期 8, 页码 1859-1871出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2016.1265113
关键词
Immune reconstitution; allogeneic hematopoietic stem cell transplant; T-cell depletion
资金
- National Institutes of Health [P01 CA23766]
- NIH/NCI Cancer Center Support Grant [P30 CA008748]
- NIH [U01HL069315]
- Translational and Integrative Medicine Research Fund of Memorial Sloan-Kettering Cancer Center
- Cycle for Survival
- New York Community Trust
- When Everyone Survives
- European Union [602587]
Infection, relapse, and GVHD can complicate allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although the effect of poor immune recovery on infection risk is well-established, there are limited data on the effect of immune reconstitution on relapse and survival, especially following T-cell depletion (TCD). To characterize the pattern of immune reconstitution in the first year after transplant and its effects on survival and relapse, we performed a retrospective study in 375 recipients of a myeloablative TCD allo-HSCT for hematologic malignancies. We noted that different subsets recover sequentially, CD8+T cells first, followed by total CD4+and naive CD4+T cells, indicating thymic recovery during the first year after HSCT. In the multivariate model, a fully HLA-matched donor and recovery of T-cell function, assessed by PHA response at 6 months, were the only factors independently associated with OS and EFS. In conclusion, T-cell recovery is an important predictor of outcome after TCD allo-HSCT.
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