期刊
BIOMATERIALS SCIENCE
卷 7, 期 5, 页码 1825-1832出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8bm01669k
关键词
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资金
- National Key Research and Development Program of China [2018YFC1105702, 2016YFA0203700]
- National Natural Science Foundation of China for Innovative Research Groups [51621002]
- NSFC [51572083, 51572084, 51461165202, 51472085]
- Program of Shanghai Academic/Technology Research Leader [18XD1401400]
- Basic Research Program of Shanghai [17JC1404702]
- Shanghai Rising-Star Program [16QA1401300]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- 111 project [B14018]
- Fundamental Research Funds for Central Universities [222201718002]
As drug-delivery carriers for cancer chemotherapy, gatekeeper-capped mesoporous silica nanoparticles (MSNs) have been widely studied due to their high drug-loading capability, controlled drug release property and good biocompatibility. However, the currently reported gatekeeper-capped MSNs suffer from complex synthetic procedures, potential toxicity of gatekeepers, unsatisfactory control on drug stimuli-release, etc. In this work, we develop a simple but efficient approach to fabricate PEGylated organosilica-capped mesoporous silica nanoparticles (POMSNs) by employing a disulfide-doped organosilica coating as the gatekeeper formed by the hydrolysis and condensation of a silane coupling agent 3-(mercaptopropyl) trimethoxysilane (MPTMS) to block the mesopores of MSNs. Owing to the glutathione (GSH)-responsive biodegradation behavior of the disulfide-doped organosilica gatekeeper, the DOX-loaded POMSNs exhibit only 20% cell viability towards SMMC-7721 tumor cells, and almost no toxicity towards L-02 cells at a DOX concentration of 50 mu g mL(-1) was measured, demonstrating their selective cytotoxicity in vitro. More importantly, it is demonstrated that the DOX-loaded POMSNs exhibit a tumor inhibition rate of 71.3% and negligible systematic toxicity. Consequently, the resultant POMSNs show great potential as drug nanocarriers for redox-responsive drug release and passive-targeting tumor chemotherapy.
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