期刊
LEUKEMIA & LYMPHOMA
卷 59, 期 4, 页码 911-917出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2017.1342822
关键词
Chronic lymphocytic leukemia; bone marrow transplant; squamous cell carcinoma; HPV; polyomavirus
资金
- Center for Infection Research in Cancer, Moffitt Cancer Center
- Tissue Core at the H. Lee Moffitt Cancer Center & Research Institute, an NCI-designated Comprehensive Cancer Center [P30-CA076292]
- Collaborative Data Services Core at the H. Lee Moffitt Cancer Center & Research Institute, an NCI-designated Comprehensive Cancer Center [P30-CA076292]
- NATIONAL CANCER INSTITUTE [K23CA201594, P30CA076292] Funding Source: NIH RePORTER
The role of cutaneous viral infections in the development of non-melanoma skin cancer (NMSC), including cutaneous squamous cell carcinoma (SCC), among chronic lymphocytic leukemia (CLL) and blood and marrow transplant (BMT) patients is not established. CLL (n=977) and BMT (n=3587) patients treated at the Moffitt Cancer Center were included in a retrospective cohort study. Human papillomavirus (HPV) and human polyomavirus (HPyV) DNA were examined in a subset of incident SCC tumors. Five-year cumulative incidence of NMSC was 1.42% in both BMT (n=31 NMSCs) and CLL (n=18 NMSCs) cohorts. Of the nine SCC tumors examined from each cohort, 22.2% and 33.3% were positive for viral DNA in the transplant (HPV 65, MCV) and CLL (HPV 38, HPV 15, HPyV6) cohort, respectively. Enhanced skin cancer screening of BMT/CLL patients should be conducted to better capture incident NMSCs and examine the role of viral infections in these tumors.
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